John Lew

Biography

Dr. Lew received his Ph.D. in Biochemistry and Molecular Biology (1993) at the University of Calgary, Alberta. His thesis work focused on the discovery of a novel cyclin-dependent protein kinase, cdk5/p35, and its specific involvement in neuron function. As a Postdoctoral Fellow of the MRC of Canada, Dr. Lew pursued his interest in protein kinase structure and function at the University of California, San Diego, where he studied the catalytic mechanism of cAMP-dependent protein kinase. His research at UCSB is focused on understanding the cellular mechanisms that lead to Alzheimer's Disease on a molecular biological, biochemical, structural and mechanistic level.

Research

Our laboratory has had a long standing interest in protein kinases and signal transduction, and recently has focused on the molecular mechanisms of Alzheimer's Disease and related dementias. We employ a multidisciplinary approach combining the methods of protein purification, molecular cloning, genetic engineering, protein chemistry, and kinetic and biophysical analysis to investigate the cellular mechanisms that lead to dementia, on both a molecular biological and detailed structure/mechanistic level. The research in our laboratory falls into two main projects: